• NU 1025 Kim et al found that hydroxydopamine OHDA promoted

  2025-01-09

  

  Kim et al. (2013) found that 6-hydroxydopamine (6-OHDA) promoted the atrophy of dopaminergic neurons associated with the activation of poly (ADP-ribose) polymerase (PARP), the translocation of apoptosis inductor factor (AIF) and the depletion of ATP. An increase in p-AMPK and pS6K (upstream kinase o

• br Results br Discussion Using primarily an electrophysiolog

  2025-01-09

  

  Results Discussion Using primarily an electrophysiological analysis of dysbindin-deficient hippocampal neurons in cultures and slices, we have uncovered a previously unreported role for dysbindin in enhancing CA3–CA1 AMPAR-mediated transmission. An earlier study, however, has reported a reduct

• br Perspectives br Acknowledgments This investigation was su

  2025-01-09

  

  Perspectives Acknowledgments This investigation was supported by a Research Grant 2010/01385-5 from FAPESP (Sao Paulo Research Foundation, Brazil). P.F.S. was recipient of a CNPq (National Council for Scientific and Technological Development, Brazil) productivity grant. R.F.A. was recipient of

• While high fat diet models of insulin resistance are accepta

  2025-01-09

  

  While high-fat diet models of insulin resistance are acceptable approaches for the study of pre-diabetes in humans, they are not suitable for modeling progression towards established type2 diabetes. The pattern of activation of the lipoxygenase pathway in pre-clinical models of type2 diabetes has no

• br Current therapies for metabolic diseases Inborn errors

  2025-01-09

  

  Current therapies for metabolic diseases Inborn errors of metabolism caused by deficiency of particular enzymes due to loss of function mutations or deletions have been treated by decreasing the intake of the enzymatic substrate, supplementation with an essential cofactor or vitamin, increasing m

• Differentiation of skeletal myoblasts is a tightly orchestra

  2025-01-09

  

  Differentiation of skeletal myoblasts is a tightly orchestrated process that involves myoblast proliferation, DNA repair modulator withdrawal, expression of muscle-specific genes, and fusion into multinucleated myofibers (Horsley and Pavlath, 2004; Krauss, 2010). The maintenance of muscle mass is im

• During the course of our

  2025-01-08

  

  During the course of our ACK1 inhibitor program, a high-throughput screening (HTS) campaign of our internal sample collection was conducted. A series of -aryl pyrimidine-5-carboxamides of the general structure () was identified. Earlier studies of the structure–activity relationship (SAR) of ident

• Actin is capable of polymerizing spontaneously However this

  2025-01-08

  

  Actin is capable of polymerizing spontaneously. However, this process is relatively slow and kinetically unfavorable in cells. Formation of Viroptic dimers and trimers, which can easily disassemble due to their instability, is a rate-determining step in actin polymerization [5], [6]. The shape and t

• Glutamyl cysteine peptide The structure of LO is divided in

  2025-01-08

  

  The structure of 5-LO is divided in two domains, the catalytic C-terminal domain and the N-terminal regulatory C2-like domain (C2ld) [59,60]. The C2ld spans the Glutamyl cysteine peptide 1-114 and is responsible for translocation and binding of calcium and membranes [61–63]. The catalytic domain is

• Defining the multiple roles of autophagy in stroke has been

  2025-01-08

  

  Defining the multiple roles of autophagy in stroke has been a rapidly evolving and exciting venue for translational research, with innovative products being applied from bench to bedside. Spanning pharmacological pathway manipulation and functional experimental validation, altered autophagy activati

• Evidences have suggested that impairment of CK

  2025-01-08

  

  Evidences have suggested that impairment of CK activity contributes to inhibition of Na+, K+-ATPase and H+-ATPase activities during infectious diseases, since these ATPases are dependent of ATP, as observed by Baldissera et al. [31] in fish experimentally infected by Aeromonas caviae. We observed th

• br Metabolic effects of apelin in obesity and type diabetes

  2025-01-08

  

  Metabolic effects of apelin in obesity and type 2 diabetes Mice fed a high fat diet (HFD) for several weeks become obese, hyperglycemic, hyperinsulinemic and insulin resistant. Acute apelin treatment by intravenous injection or by infusion during a hyperinsulinemic–euglycemic clamp in obese and i

• Iloperidone therapy br Materials and methods br Results br D

  2025-01-08

  

  Materials and methods Results Discussion In this study, the orphan receptor GPR25 was cloned from several representative vertebrate species including zebrafish. Although the overall amino Iloperidone therapy sequence identity among these species is not high (38–52%), our synteny analysis c

• br Antibiotic drug discovery approaches Traditionally

  2025-01-07

  

  Antibiotic drug discovery approaches Traditionally, novel 9-Phenanthrol were largely discovered by phenotypic screening approaches of various sources of compounds, such as natural products isolated from extracts of soil microbes and semi-synthetic or fully synthetic compound libraries derived fr

• The excellent safety profile of solanezumab and encouraging

  2025-01-07

  

  The excellent safety profile of solanezumab and encouraging trends in the exploratory analyses in mild AD led to its inclusion in two secondary prevention trials, which are continuing in the hope that earlier intervention may yield more substantial benefit. The A4 study (NCT02008357) started in Febr

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